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A compounding pharmacy in Nashville, Tennessee, that was producing tens of thousands of doses of compounded weight-loss medications shut down last year

In adults with obesity and knee osteoarthritis (mean baseline weight 248.5 lbs / 112.7 kg), retatrutide at 12 mg produced 28.7% mean weight loss at 68 weeks an average of 71.2 lbs lost

Key Takeaways Ozempic helps control blood sugar levels but may cause sleep issues like insomnia

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However, there is a lack of research on GLP-1 on osteoclasts, and increased research in this area, as well as long-term dynamic monitoring, will help determine the effects of GLP-1 on bone and the specific mechanisms