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In summary, these strategies support the preservation of lean mass, functional capacity, and safety in older adults, while enabling the mitochondrial, metabolic, and broader healthspan-supporting benefits of GLP-1 RAs

Approval requires bioequivalence to the reference product

The STEP 1 trial extension the largest semaglutide follow-up study found that participants regained roughly two-thirds of their prior weight loss within 52 weeks of stopping the drug

Ex-4 enhances the activities of key antioxidant enzymes in hippocampal mitochondria, including catalase, manganese superoxide dismutase, and glutathione peroxidase, reversing AGE-dependent decline

State officials acknowledge the drugs work but say they cannot afford to keep paying for them, especially as they brace for federal budget cuts in the coming years