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If one averages the effect on A1c of the highest doses for each drug in a specific drug class the reductions in A1c for each class of drug are metformin 1.09%, sulfonylureas 1.0%, TZDs 0.95%, DPP-4 inhibitors 0.66%, SGLT2 inhibitors 0.83%, and GLP-1 RAs 1.24%

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Mutation of F367 6.56b into Ala, Ile, and His decreased GLP-1 affinity and potency by 72-fold, 20-fold, and 131-fold, respectively (Yang et al., 2016)

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