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Chen Zhiyi of Nanhua University and others designed a kind of ultrasound-responsive bacteria, which can induce the expression of foreign gene IFN- in an ultrasound-controlled way, and improve the anti-tumor efficacy of the engineering bacteria in vitro and in vivo (42)
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Lancet 2023;401:2113-23
Long-Term Tolerability: We need to know if the side effects remain manageable over years of continuous use
