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Enhanced GLP-1 secretion has been suggested to be a major mechanism underlying enhanced insulin secretion after bariatric surgery because blockade of GLP-1 action by treatment with the pharmacological antagonist exendin-9 decreased insulin secretion and ameliorated post-surgical glucose handling in both mice and humans [144]

Just like in pancreatic cells [87,95], the activation of GLP-1 also modulates the electrical properties in hypothalamic neurons

For patients who have avoided weight loss injections due to needle-anxiety or those managing weekly injections this once-daily GLP-1 pill offers a needle-free alternative

For chronic weight management, Semaglutide, in combination with lifestyle modifications, assists in achieving weight loss