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The SURMOUNT-1 data showed average losses of around 22% of body weight at 72 weeks for the highest dose group, meaning 50 pounds from 280 pounds falls comfortably within the average for this medication

Conversely, GLP-1RAs may exert direct effects on the brain, depending on their ability to cross the bloodbrain barrier (BBB)

Over-the-counter vaginal moisturizers and lubricants are first-line treatments, and low-dose vaginal estrogen is available by prescription for more significant symptoms

In the STEP TEENS trial, nearly three-quarters of participants improved their BMI category by at least one level, and over 40% reached a BMI below the obesity threshold (33)

Classical examples include thalidomide and aspirin, where toxicity profiles diverged significantly between rodents and humans