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Common signs include: Feeling full faster Eating smaller portions Reduced snacking Fewer cravings for sugary foods Gradual weight loss Improved energy levels More control over eating habits Progress often occurs gradually rather than immediately

Semaglutide can attenuate inflammation in MASLD by downregulating the IRE1-XBP1-C/EBP (inositol-requiring transmembrane kinase/endonuclease-1-X-box binding protein 1-CCAAT/enhancer binding protein ) pathway in macrophages ( 2 ( 4.1.2 GLP-1RAs regulate the immune cells to protect the liver against fibrosis and neoplasia Exenatide and liraglutide can elevate cAMP levels and reduce the M1/M2 ratio through the cAMP-PKA-STAT3 pathway, resulting in amelioration of injured liver function and liver inflammation (Somm et al., 2021)

Reference: Keskin, U., Altin, E., Kara, M

Role of weight loss-induced prediabetes remission in the prevention of type 2 diabetes: time to improve diabetes prevention

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