glp 1 parkinson's disease and neuroprotection Beyond insulin: The Intriguing role of GLP-1 in The protective role of GLP-1

It acts on GIP receptor five times over GLP-1 receptor [50]

All other GLP-1 medications, including Ozempic and Mounjaro, are currently FDA-indicated for people diagnosed with Type 2 diabetes

The risk for thyroid cancer over a maximum of 8 years of follow-up did not differ between GLP-1 medication users and adults using an SGLT2 inhibitor, DPP-IV inhibitor or sulfonylurea, though GLP-1 users did have a higher thyroid cancer risk during the first year of therapy

doi: 10.1016/j.cmet.2021.12.010 Summary Keywords GIP, GLP-1, obesity, weight loss, tirzepatide, GLP-1R agonists, GIP receptor agonists, Citation Zaffina I, Pelle MC, Armentaro G, Giofr F, Cassano V, Sciacqua A and Arturi F (2023) Effect of dual glucose-dependent insulinotropic peptide/glucagon-like peptide-1 receptor agonist on weight loss in subjects with obesity

While both CVO and the hypothalamus are important, the hypothalamus is likely more central to the direct regulation of appetite and satiety through GLP-1 signaling