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10.1111/j.1476-5381.2010.01107.x 42 GandasiN

The peptide in a liquid formulation is just as temperature-sensitive as an injectable

Therapy with dulaglutide allows many patients to reach and maintain target HbA1c without insulin and sulfonylureas, eliminating the associated hypoglycemia risk

Liraglutide improves memory in obese patients with prediabetes or early type 2 diabetes: A randomized, controlled study

Systemic GLP-1 receptor deficiency impairs GLP-1-induced anorexia as anticipated.41 However, these mice do not display alterations in baseline body weight, suggesting that GLP-1 receptor is not critical for body weight regulation under basal conditions.41 Notably, subsequent investigations revealed that both male and female mice lacking systemic GLP-1 receptor are resistant to diet-induced obesity.39,42 Focusing on central mechanisms, intracerebroventricular administration of GLP-1 failed to modulate feeding behavior in GLP-1 receptor global knockout mice.41 Central inhibition of GLP-1 receptor disrupts glucose homeostasis and reduces food intake, whereas peripheral GLP-1 receptor inactivation impairs glucose-stimulated insulin secretion, diminishes glucose clearance, elevates glucagon levels, and accelerates gastric emptying