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In clinical trials for Ozempic (SUSTAIN programme), patients experienced weight reductions of approximately 3.5-6.5kg over 30-56 weeks, depending on the dose

Lipoatrophy associated with the use of insulin analogues: a new case associated with the use of insulin glargine and review of the literature

The difference between the two dosages and the rates of NAION may indicate a dose dependent increase in risk of NAION. Benjamin Bert, MD Future research should focus on this potential dose-dependent increase in adverse events with the GLP-1 medications, Bert continued

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So, its safety and efficacy remain uncertain