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Aetna's Prior Authorization Requirements To get approved for a GLP-1 weight loss medication through Aetna, you typically need to meet all of the following criteria: BMI of 30 or higher , or a BMI of 27 or higher with at least one weight-related condition (type 2 diabetes, hypertension, dyslipidemia, or obstructive sleep apnea) Documentation of a prior weight management attempt lasting at least 6 months, which can include a structured diet program, behavioral counseling, or a previous medication trial Prescriber must be a licensed physician or advanced practice provider, and some plans require a specialist referral Aetna's clinical policy bulletin (CPB 0784) outlines these requirements in detail

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Moreover, it downregulates the protein levels of cell proliferation marker PCNA, decreases cell viability and number, and upregulates the protein levels of pro-apoptotic markers [91]