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The anti-inflammatory properties of glucagon like peptide-1 receptor agonists The glucagon like peptide-1 receptor agonists (GLP-1 RAs) are a glucose-lowering class of drugs that acts by mimicking the native GLP1 action, a peptide hormone synthesized by bowel endocrine L-cells and physiologically degraded by dipeptidyl-peptidase 4

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Researchers are also evaluating retatrutide for type 2 diabetes (TRIUMPH-2), cardiovascular outcomes (TRIUMPH-3), and other conditions such as metabolic dysfunction-associated steatotic liver disease (MASLD)

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However, the delayed gastric emptying associated with GLP-1 RAs complicates these traditional protocols and introduces a potential risk for residual gastric contents (RGC) and aspiration, even when patients adhere to the recommended fasting times (Joshi et al