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Beyond Weight Loss:Evaluating therapies based on composition of weight loss (fat vs

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The kidney and cardiovascular outcome trials

Research published in clinical trials of semaglutide shows that up to 40% of total weight lost can be lean muscle mass when protein intake is insufficient

At the level used in this study it is not expected that long term consumption might induce a cumulative toxic effect on kidney or liver associated with the anti-nutrient compounds that are originally present in the leaves, such as saponins, tannins, terpenes or alkaloids [36]