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Participants in one trial lost around 15% of their body weight over 72 weeks, with many losing more than 20% at a higher dosage

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Eligible participants had a baseline HbA1c of 7.0% to 9.5% (SURPASS-1), 7.0% to 10.5% (SURPASS-2, -3, and -5) or 7.5% to 10.5% (SURPASS-4)

Importantly, these medications carry a boxed warning and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)