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Some people report difficulty sleeping during the early weeks of treatment, which can further contribute to tiredness and decreased energy

Most patients experience some reduction in appetite and improvement in blood sugar control within the first 1-2 weeks

In patients with T2DM, adherence to GLP-1 RAs therapy is often suboptimal, although it tends to be higher among those receiving once-weekly formulations (57)

However, while the processes of exocytosis are similar to those in neuronal cells, the kinetics of release are quite different

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