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HbA1c reductions that rival insulin Across the SURPASS trial program, tirzepatide reduced HbA1c by up to 2.24%, bringing many participants to levels below the diabetic threshold
The reality is quieter
Diarrhea, constipation, vomiting, abdominal pain, and decreased appetite round out the typical complaints
A 2025 paper suggested the drugs may drive depression and suicidal ideation specifically in people with a genetic predisposition toward low dopamine function
However, GLP-1s accounted for over 8% of all Medicaid prescription drug spending before rebates in 2024 (up from 1% in 2019)
