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For treatments that have known serious adverse effects (e.g., anti-amyloid antibody therapies), a personalized approach to treatment needs to include the consideration of the riskbenefit ratio, which may be affected by age, biomarker status, and other risk factors (Boxer and Sperling, 2023)

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VESPER-1: the durability signal In a 32-week exploratory extension (Part B) of VESPER-1, Pfizer reports a 15.9% non-placebo-adjusted weight loss with no plateau observed at 32 weeks on 2.4 mg weekly berobenatide in participants who escalated from placebo to active drug

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