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These regions mediate reward, motivation, and AUD processes, and they are important for other gutbrain axis peptides to regulate alcohol-related responses in rodents [for a review, see Shevchouk et al

Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes
Glucagon affects sodium handling in kidneys and may enhance natriuresis (salt excretion) beyond GLP-1/GIP effects alone

The trial looked at the safety and effectiveness of tirzepatide in two scenarios: Continuing to take tirzepatide at the maximum tolerated dose (10 or 15 milligrams [mg], depending on the patient) after initial treatment on that dose Lowering the dose to 5 mg after initial treatment to maintain weight loss
