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If efficacy suddenly decreases or side effects change substantially despite using the same dose, suspect potency issues

Treatment with 30 g/kg AC3174, an exenatide analog, administered via an osmotic pump for 28 days in Lep ob mice on a high trans -fat diet significantly reduced liver weight, hepatic lipid accumulation, and plasma alanine transaminase levels in comparison with pair-fed, weight-matched controls (30)

Costs can be in the single millions for small molecules compared to mid- to high tens of millions for peptides

This convenient injectable peptide delivery method supports better treatment adherence and offers ease of use for patients managing weight loss or type 2 diabetes

Through promoting lipolysis in adipose tissue, IR is believed to exacerbate lipotoxicity, which is positive feedback further aggravating the imbalance of metabolism (121)