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Because orforglipron is taken once a day in pill form, it may be easier for patients to stay consistent with treatment

Experimental models on Snord116-KO mice showed PWS features such as hyperphagia (156159)

Switching to an oral pill may appeal to those who dislike injections or want a simpler dosing routine, while a lower injectable dose may offer a cheaper option that may also result in less adverse events

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In line with this, the complete abolition of -arrestin signaling prolonged anti-hyperglycemic effects (superior glucose tolerance after 72 h compared to semaglutide) and enhanced chronic weight loss in mice [52]