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Phase 2: titration doses (5mg and 7.5mg, weeks 5 through 12) This is where most people notice significant appetite changes
GIP receptor activation enhances insulin secretion and suppresses glucagon in a glucose-dependent manner similar to GLP-1
The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets
Some people find tirzepatide easier to tolerate, while others have a smoother experience on semaglutide a variability driven by factors like genetics, diet, and individual dose escalation protocols
1, Heimbrger et al
