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Metabolism The metabolism of common GLP-1 RAs varies across agents: Exenatide undergoes hydrolysis in the kidneys and liver, producing smaller inactive peptides excreted via the kidneys (23)

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The last sentence is odd In a separate study, no apparent effect on the rate of gastric emptying was observed with semaglutide 2.4 mg. The study isnt cited so Im not clear if they mean that no apparent effect of delayed gastric emptying on the absorption of concomitantly taken drugs was observed, or if they are saying that taking semaglutide 2.4mg did not have an effect on the rate of gastric emptying which doesnt make sense since delayed gastric emptying is a well-studied effect of the drug

Clara, R., Langhans, W., & Mansouri, A

Standard dose escalation The FDA-approved dosing protocol for tirzepatide starts at 2.5 milligrams once weekly for the first four weeks