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3 When lifestyle changes are not enough to maintain appropriate blood glucose levels, pharmacologic therapy may be required to prevent complications, including high blood pressure, cardiovascular disease, diabetic retinopathy, and kidney damage

AGEs and AGE/RAGE interactions result in oxidative stress in diabetic neuropathy, activate microglia, and increase pro-inflammatory cytokine levels, which contribute to neurological dysfunction, including impaired pain perception [68]

doi: 10.1007/s40618-014-0156-8

TRT often leads to heightened libido and better sexual performance, addressing concerns like erectile dysfunction

Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice