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doi: 10.1073/pnas.91.21.9770
The headline figure that safety-focused researchers point to first is the completion rate
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Introducing highly fermentable prebiotics into a gut that is currently overgrown with pathogenic or histamine-producing bacteria can trigger a "flare-up." The harmful bacteria will rapidly ferment the new fiber, producing excess gas, LPS, and histamine, which can temporarily worsen leaky gut and provoke a severe mast cell reaction
Some commercial plans are expected to eliminate weight loss coverage entirely by 2026 to avoid premium hikes
