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When to seek medical advice : If you suspect pancreatitis (severe abdominal pain radiating to the back, nausea, vomiting), stop your GLP-1 medication immediately and seek urgent medical attention via NHS 111, 999, or A&E Severe or worsening gastrointestinal symptoms despite probiotic use New symptoms such as persistent abdominal pain, bloody stools, or unexplained weight loss Signs of infection including fever, particularly if immunocompromised Before starting probiotics , women should inform their healthcare provider, particularly if they have diabetes requiring careful monitoring, as any dietary changes can affect glycaemic control

However, several theories exist based on the known actions of these drugs: Neurological Effects: GLP-1 receptors are found throughout the central and peripheral nervous systems

Endocrinology (2009) 150(7):29973001

At approved weight-loss doses, caloric intake typically decreases in a consistent and measurable way

Some patients find they tolerate exenatide better than semaglutide