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Real-World Factors That Influence Your Timeline Your transformation speed depends on baseline weight, starting diet quality, exercise consistency, sleep patterns, and stress management

A naturally occurring hormone, GLP-1 is produced in the small intestine

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Because retatrutide includes GLP-1 agonism (which semaglutide was providing) plus GIP and glucagon agonism, the transition should not result in loss of appetite suppression during the switch
