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Bloomgarden Z

Targeting neuroinflammation in neurodegenerative diseases has been explored using cyclooxygenase inhibitors, but it has mostly been unsuccessful

Dual-agonist combinations are being developed for diabetes (see Tirzepatide from Eli Lilly or BI 456906 from Zealand Pharma ), but KP405 has been designed to penetrate the blood brain barrier for testing in neurodegenerative conditions

A recent randomized placebo-controlled trial published by Scirica et al, known as SAVOR-TIMI 53, found no significant difference in ischemic events but did observe higher hospitalizations for heart failure with saxagliptin

PMID 27142267