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Description
Obesity medications are failing because people regain weight after stopping them
Eli Lilly reported another success in a study pitting its once-daily oral GLP-1 therapy Orforglipron against a competing type 2 DM therapy, this time AstraZeneca's SGLT2I Farxiga (Dapagliflozin)
Trial registration ClinicalTrials.gov Identifier: NCT06166368
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Pasireotide drastically inhibited GLP-1 secretion induced by Gs-coupled receptor stimulation through SSTR5-Gi-dependent inhibition of cAMP levels, suggesting that the main pathway was completely blocked
