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GLP-1s are not a substitute for hormone therapy, which remains the most effective treatment for most menopause symptoms

Women should aim for 25-35g per day while men 30-40g+ a day

However, the exact mechanism of SCFA-induced gut peptide release is controversial, as SCFAs may activate EECs via basolateral sensing mechanisms, similar to LCFAs

Known as the incretin effect, GLP-1 and its synergetic sister hormone glucose-dependent insulinotropic polypeptide (GIP), are rapidly released by lower enteroendocrine L-cells (GLP-1) or upper enteroendocrine K-cells (GIP) in the gut following food intake and rising circulatory glucose levels to augment the glucose-stimulated release of insulin by pancreatic cells

Your gut produces this hormone after eating