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Yet GLP-1R knockdown in Sim1 neurons did result in a significant reduction in energy expenditure, in contrary to results from whole-body or hypothalamic GLP-1R knockout models

Body weight reductions of at least 20% were achieved in 50% (10 mg) and 57% (15 mg) of participants taking tirzepatide compared with only 3% of those taking placebo

Nausea, diarrhea, vomiting, and constipation are frequently reported, especially when starting the medication or increasing the dose

Instead, tirzepatide creates conditions in the body that make fat loss more likely and easier to maintain long term

Use separate injection sites, at least 2 inches apart, typically alternating sides of the abdomen or using one abdominal site and one thigh site