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The broader comparison of injectable vs oral peptides examines the bioavailability differences that make injection the preferred route for most peptide researchers

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A recent study in mice has demonstrated that liraglutide is shuttled to target cells in the mediobasal hypothalamus by tanycytes containing GLP-1 receptors, to exert its effect on food intake, body weight and fat mass, and fatty acid oxidation [89]

We [also] found that semaglutide acts via a reward area [in the brain] called nucleus accumbens. The studys main limitation is that it used rats and mice