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In patients with mCRPC whose disease progressed during or after treatment with docetaxel, cabazitaxel was shown to improve survival compared with mitoxantrone in a randomized trial (NCT00417079).[65] In this trial, 755 such men were treated with prednisone (10 mg PO qd) and randomly assigned to receive either cabazitaxel (25 mg/m2 IV) or mitoxantrone (12 mg/m2 IV) every 3 weeks.[65][Level of evidence A1] Median OS was 15.1 months in the cabazitaxel arm and 12.7 months in the mitoxantrone study arm (HR death, 0.70

The comparison between semaglutide, tirzepatide, and retatrutide reveals the rapidly advancing science of GLP-1 based treatments

doi: 10.1677/JOE-09-0132 46 GilmanCPPerryTFurukawaKGriegNHEganJMMattsonMP
