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However, this landscape could shift next year with the anticipated approval of: The oral version of Wegovy for obesity treatment (approved just yesterday) Eli Lillys Orforglipron

In addition to their glycemic effects, DPP-4 inhibitors have the potential to decrease bone resorption, increase bone formation, and reduce the incidence of osteoporosis and fractures

doi: 10.1111/j.1748-1716.2009.01971.x 18 HawleySAGadallaAEOlsenGSHardieDG

Patients with higher starting BMIs also tend to experience more pronounced metabolic adaptation after weight loss, making maintenance dosing or longer treatment courses more important for sustained results

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