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Regarding renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria but not on hard kidney endpoints

While newly approved pharmacotherapies such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) show efficacy, their clinical utility remains constrained by dose-dependent gastrointestinal complications, underscoring the urgent need for safer alternatives

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A-RDN induced significant increases in diuretic and natriuretic responses to GLP-1 in HF (urine flow 96.01.9 vs

The GLP-1 receptor assay is a powerful tool for the identification of GLP-1 receptor agonists aimed at treating obesity and type 2 diabetes