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Although it appears surprising that the intracellular [Ca 2+ ] response to GABA was almost completely abolished by the specific GABA A receptor antagonist bicuculline, despite the evidence suggesting that GABA C receptor activation contributes to the GABA response, similar findings in neurones have recently led to the proposal that GABA A and GABA C receptor subunits can coassemble to form heteromeric channels with mixed properties (Hartmann et al

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