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88,94 These micoglial states have been termed M1 and M2 phenotypes (adapted from T-helper cell 1 and 2), although these 2 polarized states are too constricting in relation to micoglia, as they have the plasticity to heterogeniously change phenotype to optimize function in response to an almost endless variety of envioronmental challenges

Clinical studies suggest potential benefits, particularly in nicotine and alcohol use disorders

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Others need the additional support of medication

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