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For this reason, the effect of Notch inhibition is not selective for L-cells, and the number of K, goblet, and Paneth cells also increases
FDA-approved medications for Cushing's syndrome include osilodrostat (Isturisa), levoketoconazole (Recorlev), pasireotide (Signifor), and mifepristone (Korlym)the latter specifically indicated for hyperglycemia secondary to Cushing's syndrome

These patients need b12 supplementation as a baseline requirement, separate from any theoretical benefits of combination products
Protection against nephropathy with fenofibrate in type 2 diabetes mellitus: the FIELD study

This class of drugs can exacerbate the symptoms of diabetic gastroparesis. Wegovy Gastric Emptying Warning In July 2023, The American Society of Anesthesiologists (ASA) highlighted concerns about delayed gastric emptying caused by Wegovy and Ozempic, especially for those set to undergo surgeries
