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Although diabetes duration was not an inclusion criterion in the SURPASS trials, individuals enrolled in SURPASS-1 were previously untreated, those in SURPASS-2 were treated with metformin alone, and those in SURPASS-3 were treated with metformin with or without an SGLT2i, while only SURPASS-5 and SURPASS-6 included participants using insulin at baseline, suggesting that the average diabetes duration at inclusion in these trials may have been relatively short

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Many patients begin to experience weight loss within the first few weeks, but significant results are usually achieved after several months of consistent treatment

Reaching your goal weight is a major accomplishment, but maintaining that weight is the next challenge

Patients should inspect injection sites regularly for signs of lipohypertrophy, tenderness, or skin changes, and avoid using affected areas until complete resolution occurs