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While it is generally safe, melatonin is a potent hormone, originally extracted from a cows pineal gland, and it can have a number of adverse effects and drug interactions, ranging from nausea to increased blood pressure

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*In a 68- and 72-week clinical trial studying Semaglutide in patients without diabetes and with BMI 30, or BMI 27 with a weight-related condition, the average weight loss was 15% and 20%, when paired with diet and exercise changes (compared to 2.4% and 3.1%, respectively, with diet and exercise alone)

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pic.twitter.com/5qnR3FIKgl Alexis Ohanian (@alexisohanian) September 8, 2025 So now, Ohanian says he is making self-care part of the routine