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Estrogen exerts its action by binding to estrogen receptor (ER), ER, and G-protein coupled receptors (GPCR) and is extensively metabolized by the CYP450 system [6]

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However, the risk for thyroid cancer was significantly higher within the first year after GLP-1RA initiation and was amplified in the overall as-treated analysis that censored patients when therapy was discontinued or another medication was added. The research team indicates this could be a sign that GLP-1 users are being screened for thyroid cancer at a higher rate than other diabetes drugs, resulting in a spike in diagnoses in the first year of taking the drug