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and the PEGylated agonist NLY01, which on this account does not effectively reach the brain despite being engineered for penetrance, was negative in a Phase 2 Parkinsons trial [12,13]
Also, we know that these drugs do not cross the blood brain barrier

Additional studies, including randomised controlled trials, will be needed to corroborate our findings and to explore the full therapeutic potential of the GLP-1 receptor agonist-SGLT-2 inhibitor combination among patients with type 2 diabetes
3 Results of reduced GIP receptor activation in humans Some GIP receptor antagonists have contributed to the elucidation of the physiological properties of endogenous GIP

According to the World Health Organization (WHO), it is estimated that around 77 million adults are presently living with type 2 diabetes and nearly 25 million are classified as prediabetic