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Notably, in rat 6-OHDA models, DA-CH5 and exendin-4 have been suggested to exert their neuroprotective by inducing autophagy and inhibiting apoptosis, particularly by enhancing autophagic activity and reducing the Bax/Bcl-2 and active caspase-3/caspase-3 ratios [35]

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Both compounds reduce liver fat, but mazdutide provides strong hepatic benefits through its glucagon component without the additional gastrointestinal burden of triple agonism