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Inhibitors of the peptidomimetic class such as saxagliptin and vildagliptin mimic the dipeptide terminal of DPP4 at the cleavage site of the incretin hormone substrates

doi: 10.1007/s00125-023-05969-6 82 Sparre-UlrichAHSparre-UlrichAHGabeMNGasbjergLSChristiansenCBSvendsenBHartmannet al

Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM, et al

On average, patients using these medications can achieve significant reductions in HbA1c (a marker of blood sugar control) and weight loss of around 314% of their body weight, depending on the medication and lifestyle changes

Therefore, the combined use of GLP-1 RAs with therapies targeting intrahepatic pathways, such as thyroid hormone receptor (THR-) agonists, fibroblast growth factor-21 (FGF21) analogues, and peroxisome proliferator-activated receptor (PPAR) agonists, presents a promising approach for MASH treatment