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The study, based on millions of FDA side-effect reports, found the risk signal was nearly five times stronger for Wegovy than for Ozempic, despite both containing semaglutide.

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Furthermore, it had an anti-inflammatory impact via stimulating cyclic adenosine monophosphate (cAMP)/ protein kinase A (PKA)/ cAMP response element (CRE)-binding protein (CREB) signaling pathway and shifting M1/M2 macrophage polarization towards the M2