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Real-world users on tirzepatide lost approximately 12.4% of body weight at one year in a 2025 study, which is meaningfully higher than semaglutide alone

However, GLP-1RAs were associated with a marginally nonsignificant increased risk of kidney cancer (HR, 1.38 [95% CI, 0.99-1.93]

Variants in GLP1R, GIPR, and metabolic genes like FTO can support a more personalized discussion about which medication formulation or dosing protocol may be worth exploring with your provider

How should side effects be monitored and managed

This would help answer the question of whether previously reported negative outcomes in other trials were a drug-specific retinal toxicity of the GLP-1/GIP receptor agonists vs