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21 In a cohort study, Gamble et al 36 examined the risk of depression and self-harm with incretin-based therapies in patients with type 2 diabetes

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Peak concentration is reached approximately 1-hour post-dose, with steady-state achieved after 4-5 weeks

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Interestingly, it has been shown that rats consuming a 3 g meal displayed significant elevations in plasma GLP-1 within 56 min only in the hepatoportal vein and not in the vena cava [78], suggesting that, under physiological conditions, GLP-1R within the CNS is only reached by brain-derived GLP-1, since GLP-1 is also expressed by a discrete population of caudal brainstem neurons localized to neurons within the caudal (visceral) nucleus of the solitary tract (cNST) and adjacent medullary reticular formation in rodents and primates, including humans [83,84,85,86]