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Beyond improving glycemic control and promoting weight loss, GLP-1 receptor agonists have been shown to reduce vascular inflammation, improve endothelial function, enhance nitric oxide bioavailability, and reduce oxidative stress. These effects may slow the progression of atherosclerosis and improve blood flow to the lower extremities

Meanwhile, Mounjaro, Zepbound and the generic tirzepatide elevate both GLP-1 and a second anti-diabetes/anti-obesity hormone called GIP

Common genetic variation in GLP1R and insulin secretion in response to exogenous GLP-1 in nondiabetic subjects: a pilot study

Possible side effects and safety monitoring As with other medicines in the same class, the most commonly reported side effects are gastrointestinal

Drucker D, Nauck M