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Thyroid tumors appeared in animal studies but havent been confirmed in human use

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This is not necessarily a problem, but it does mean that the first injection after an extended gap may feel like a step backward more nausea, more appetite suppression, more side effects even if you've been on the same dose for months

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doi: 10.1016/0196-9781(96)00019-8

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Most patients who stop GLP-1 therapy for 2 to 4 weeks experience modest weight rebound, typically 2 to 5 pounds, though individual responses vary

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This can result in testicular shrinkage (since the testes produce testosterone) and infertility

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