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In the context of hypertrophy and cardiac remodeling, -blockers have been shown to affect signaling pathways that regulate cell growth and survival ( One significant aspect to explore is how these medications impact cellular processes at the molecular level, especially concerning metabolic pathways and signaling cascades

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Starting with a low dose and gradually increasing it, as prescribed, helps minimise gastrointestinal side effects

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They were randomized to receive either PIO (in a daily dose of 15 mg) or placebo for 24 weeks, followed by a 24-week PIO extension for those who had completed the main study