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1 Dual agonism of GIP and GLP-1 receptors is a promising new approach currently in clinical development for the treatment of diabetes, obesity, and associated complications [1] The incretin effect defines the main physiological role of GIP and GLP-1 GIP and GLP-1 increase insulin secretion following nutrient-induced secretion from the gut (incretin effect): There is a stronger insulin secretion response to oral compared to 'isoglycemic' intravenous glucose administration due to secretion and action of incretin hormones

Protein sources vary widely in texture, density, and how filling they feel

Keep a daily or weekly log of symptoms, limitations, and emotional impact

Liraglutide (Saxenda), which is administered as a daily injection, has also been proven to help individuals decrease weight without any weight regain

Back pain was reported by trial participants, but the incidence was essentially equal between Ozempic and the placebo